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2025, 08, v.43 1-10+24
可穿戴器械用于体内生理信号分子检测的研究进展
基金项目(Foundation): 国家自然科学基金(51973144)
邮箱(Email): lushenzhou@suda.edu.cn;
DOI:
摘要:

可穿戴检测技术通过非侵入式传感器与柔性电子器件融合,实现了对葡萄糖、乳酸、电解质等关键生理信号分子的实时动态监测。其突破了传统有损检测技术的局限性,借助电化学、光化学及生物化学等多模态传感途径,例如循环伏安法、光强分析和酶促反应,结合丝素蛋白基微针、碳纳米管纤维智能织物等创新材料,构建了从表皮到组织液的多层次生理信号捕获网络。当前该技术已成功应用于糖尿病动态血糖管理、运动医学乳酸监测及传染病早期筛查中,可推动医疗健康模式向预防-监测-干预闭环转型。未来,需进一步突破灵敏度与无创性矛盾,通过纳米级微针应用、智能算法优化及多源数据融合,实现临床级精准检测与舒适性的有效平衡。

Abstract:

Wearable detection technology has enabled real-time dynamic monitoring of key physiological signaling molecules such as glucose, lactate, and electrolytes through the integration of non-invasive sensors and flexible electronic devices. It breaks through the limitations of traditional destructive detection technologies, and constructs a multi-level physiological signal capture network from the epidermis to the interstitial fluid, by means of multi-modal sensing approaches such as electrochemistry, photochemistry, and biochemistry, such as, cyclic voltammetry, light intensity analysis, and enzymatic reactions, combined with innovative materials like silk fibroin-based microneedles and carbon nanotube fiber smart fabrics. This technology has been successfully applied in dynamic glucose management for diabetes, lactate monitoring in sports medicine, and early screening for infectious diseases, which can promote the transition of healthcare models toward prevention-monitoring-intervention closed-loop. In the future, it is necessary to further break through the contradiction between sensitivity and non-invasiveness, and achieve an effective balance between clinical-grade precision detection and comfort through nanoscale microneedles implementation, intelligent algorithms optimization, and multi-source data fusion.

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基本信息:

DOI:

中图分类号:TP212;R318

引用信息:

[1]崔鹏宇,王东炜,赵家豪,等.可穿戴器械用于体内生理信号分子检测的研究进展[J].产业用纺织品,2025,43(08):1-10+24.

基金信息:

国家自然科学基金(51973144)

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